быстрая доставка ~4 недели
Размер
- 100 μg
- 1000 μg
- 500 μg
Rabbit anti-Human CHI3L1 mAb (CAP) (RM17919)
- Описание
- Характеристики
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Overview
Product name Rabbit anti-Human CHI3L1 mAb (CAP) Catalog No. RM17919 Catagory Elisa Antibody Kit Application ELISA Description Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding.Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1 (By similarity).Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin .Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade (By similarity).Required for microglial phagocytosis of apoptotic neurons.Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain (By similarity).Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide (By similarity).It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro-inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB (By similarity).During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling (By similarity).Plays a role in microglial MTOR activation and metabolism (By similarity).Regulates age-related changes in microglial numbers .Triggers activation of the immune responses in macrophages and dendritic cells (PubMed:10799849).Mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity).In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival.Involved in the positive regulation of osteoclast differentiation. Immunogen Recombinant Human CHI3L1Protein Purirty Affinity purification Ig Type Rabbit IgG Formulation Supplied as a 0.2um filtered solution in PBS with 0.05%ProClin 300, PH 7.8. CrossReactivity / Storage This antibody can be stored at 2℃-8℃ for one monthwithout detectable loss of activity. Antibody products are stable for twelve months fromdate of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Application
Recommended
ConcentrationSample ELISA Capture 0.5-2ug/mL Rabbit anti-Human CHI3L1 mAb(CAP)(Cat. No.RM17919) ELISA Detection 0.025-0.1ug/mL Rabbit anti-Human CHI3L1 mAb(DET)(Cat. No.RM17920) Standard 62.5-4000pg/mL Recombinant Human CHI3L1 Protein Rabbit anti-Human CHI3L1 mAb (CAP) images
This standard curve is only for demonstration purposes. A standard curve should be generated for eachassay.
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Antibody type Matched antibody pairs Reactivity Человек Immunogen Recombinant Human CHI3L1Protein
