быстрая доставка ~4 недели
Размер
- 100 μL
- 200 μL
- 50 μL
ABCB11 Rabbit pAb (A14694)
- Описание
- Характеристики
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Overview
Product name ABCB11 Rabbit pAb Catalog No. A14694 Host species Rabbit Purification method Affinity purification Isotype IgG Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.Immunogen information
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human ABCB11 (NP_003733.2). Sequence RFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQ Gene ID Swiss Prot Synonyms BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2 Calculated MW 146kDa Observed MW 146kDa Applications
Reactivity Mouse, Rat Tested applications IF/ICC Recommended dilution - IF/ICC 1:50 - 1:200
Storage buffer Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.Key application Immunofluorescence Positive samples Rat liver Cellular location Membrane, Multi-pass membrane protein Customer validation WB(Homo sapiens,Mus musculus)
IF(Homo sapiens)
Immunofluorescence analysis of C6 cells using ABCB11 antibody (A14694) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of NIH/3T3 cells using ABCB11 antibody (A14694) at dilution of 1:100. Blue: DAPI for nuclear staining.
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Key applications Immunofluorescence Host species Кролик Antibody type Primary Antibodies Reactivity Мышь, Крыса Immunogen A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human ABCB11 (NP_003733.2). Isotype IgG