Product Information
Description | HSF1 rabbit polyclonal |
Protein full name | Heat shock factor protein 1 |
Synonyms | Hsf1, HSF1, HSTF1, Heat shock transcription factor 1 |
Immunogen | Recombinant protein corresponding to Mouse HSF1 |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Cytoplasm, Nucleus |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
IHC | Human, Mouse, Rat | 1: 500-1: 1500 | lung cancer, testis |
IF | Human, Mouse, Rat | 1: 250-1: 500 | lung cancer, testis |
Background
The HSF1 protein regulates the heat shock response (HSR) pathway in humans by acting as the major transcription factor for heat shock proteins. The HSR plays a protective role by ensuring proper folding and distribution of proteins within cells. This pathway is induced by not only temperature stress, but also by a variety of other stressors such as hypoxic conditions and exposure to contaminants. HSF1 transactivates genes for many cytoprotective proteins involved in heat shock, DNA damage repair, and metabolism. This illustrates the versatile role of HSF1 in not only the heat shock response, but also in aging and diseases.
Images
| Immunohistochemistry analysis of paraffin-embedded human lung cancer using HSF1 (GB11932) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse testis using HSF1 (GB11932) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat testis using HSF1 (GB11932) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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