Product Information
Description | E Cadherin rabbit polyclonal |
Protein full name | Cadherin-1 |
Synonyms | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO, cadherin 1, BCDS1, E-Cadherin, CAM 120/80, Epithelial cadherin |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse E Cadherin |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 98 kDa |
Observed MW. | 124 kDa |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | stomach, kidney |
Background
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
Images
| Western blot analysis of E-Cadherin (GB11868) at dilution of 1: 1000 Lane 1: A431 cell lysate Lane 2: MCF7 cell lysate Lane 3: Caco2 cell lysate Lane 4: Mouse stomach tissue lysate Lane 5: Mouse kidney tissue lysate Lane 6: Rat stomach tissue lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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