Product Information
Description | TLE 1 rabbit polyclonal |
Protein full name | Transducin-like enhancer protein 1 |
Synonyms | Tle1, TLE1, ESG, ESG1, GRG1, Transducin like enhancer of split 1, TLE family member 1, transcriptional corepressor |
Immunogen | Recombinant protein corresponding to Mouse TLE 1 |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 75 kDa |
Observed MW. | 75 kDa |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | kidney, colon, stomach, prostate |
Background
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Images
| Western blot analysis of TLE 1 (GB11898) at dilution of 1: 1000 Lane 1: HCT116 cell lysate Lane 2: Mouse kidney tissue lysate Lane 3: Mouse colon tissue lysate Lane 4: Mouse stomach tissue lysate Lane 5: Mouse prostate tissue lysate Lane 6: Rat kidney tissue lysate Lane 7: Rat colon tissue lysate Lane 8: Rat stomach tissue lysate Lane 9: Rat prostate tissue lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE: