Product Information
Description | CD63 rabbit polyclonal |
Protein full name | CD63 antigen |
Synonyms | CD63, LAMP-3, ME491, MLA1, OMA81H, TSPAN30, CD63 molecule, Lysosomal associated membrane protein 3, LAMP3, CD63 antigen, NGA, Tetraspanin-30 |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse CD63 |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Secreted,Cell membrane, Cytoplasm |
Uniprot ID |
Applications
applications | species | dilution | positive tissue |
IHC | Mouse, Rat | 1: 500-1: 1000 | lung, liver |
IF | Mouse, Rat | 1: 500-1: 1500 | lung, brain |
Background
CD63 antigen is a protein is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth, and motility. CD63 is a cell surface glycoprotein that is known to complex with integrins.CD63 is mainly associated with membranes of intracellular vesicles, although cell surface expression may be induced. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak Syndrome. Also this gene CD63 has been associated with tumor progression.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse lung using CD63 (GB11620) at dilution of 1: 750 |
| Immunohistochemistry analysis of paraffin-embedded rat lung using CD63 (GB11620) at dilution of 1: 750 |
| Immunohistochemistry analysis of paraffin-embedded mouse liver using CD63 (GB11620) at dilution of 1: 750 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat lung using CD63 (GB11620) at dilution of 1: 1500 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat brain using CD63 (GB11620) at dilution of 1: 1500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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