Product Information
Description | Cofilin rabbit polyclonal |
Protein full name | Cofilin-1 |
Synonyms | CFL1, CFL, HEL-S-15, Cofilin, Cofilin 1, 18 kDa phosphoprotein, Cofilin non musclei soform, p18 |
Immunogen | Recombinant protein corresponding to Mouse Cofilin |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Nucleus, Cell membrane, Cytoskeleton |
Uniprot ID |
Applications
applications | species | dilution | positive tissue |
IHC | Human, Mouse, Rat | 1: 1000-1: 2000 | spinal cord, heart, brain |
IF | Mouse, Rat | 1: 1000-1: 2000 | testis, ovary, kidney, lung, brain |
Background
Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a member of the ADF/cofilin family. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration.
Images
| Immunohistochemistry analysis of paraffin-embedded human mammary gland using Cofilin (GB11567) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse spinal cord using Cofilin (GB11567) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat heart using Cofilin (GB11567) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat brain using Cofilin (GB11567) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse brain using Cofilin (GB11567) at dilution of 1: 1000 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse testis using Cofilin (GB11567) at dilution of 1: 2000 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse ovary using Cofilin (GB11567) at dilution of 1: 1000 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse kidney using Cofilin (GB11567) at dilution of 1: 2000 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat lung using Cofilin (GB11567) at dilution of 1: 1000 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat brain using Cofilin (GB11567) at dilution of 1: 1000 |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide, 100 μg/ml BSA and 50% glycerol. |
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