Product Information
Description | P63 rabbit polyclonal |
Protein full name | Tumor protein 63 |
Synonyms | TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H p73L, |
Immunogen | Recombinant protein corresponding to Mouse P63 |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Nucleus |
Uniprot ID |
Applications
applications | species | dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 500-1: 1000 | lung cancer, liver, kidney, uterus |
IF | Human, Mouse, Rat | 1: 500-1: 1000 | lung cancer, liver, kidney, uterus |
Background
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates RIPK4 transcription (By similarity). Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm.
Images
| Immunohistochemistry analysis of paraffin-embedded human lung cancer using P63 (GB11396-1) at dilution of 1:600. |
| Immunohistochemistry analysis of paraffin-embedded mouse liver using P63 (GB11396-1) at dilution of 1:600. |
| Immunohistochemistry analysis of paraffin-embedded rat uterus using P63 (GB11396-1) at dilution of 1:600. |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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