Артикул
GB113650
быстрая доставка ~4 недели
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Anti -Abi-1 Rabbit pAb
- Описание
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Product Information
Description
Abi-1 rabbit polyclonal
Protein full name
Abl interactor 1
Synonyms
Abelson interactor 1, ABI-1, ABI1, Abl binding protein 4, AblBP4, E3B1, Eps8 binding protein, Nap1 binding protein, NAP1BP, SSH3BP, SSH3BP1
Immunogen
Recombinantproteincorrespondingto
Mouse Abi-1
Isotype
IgG
Purity
Affinity purification
Predicted MW.
52 kDa
Observed MW.
65kDa
Uniprot ID
Applications
Applications
Species
Dilution
Positive Tissue
WB
Mouse
1:300-1:600
brain
Background
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.
Images
Western blot analysis of Abi-1 (GB113650)
at dilution of 1: 600
Storage
Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.