Product Information
Description | E Cadherin rabbit polyclonal |
Protein full name | Cadherin-1 |
Synonyms | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO, cadherin 1, Epithelial Cadherin,E-Cadherin,CAM 120/80 |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse E Cadherin |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Cell membrane, Cytoplasm |
Uniprot ID |
Applications
applications | species | dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 500-1: 1000 | liver, stomach, colon |
IF | Human, Mouse, Rat | 1: 200-1: 500 | liver, stomach, colon |
Background
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
Images
| Immunohistochemistry analysis of paraffin-embedded human liver using E-cadherin (GB11082) at dilution of 1:1000 |
| Immunohistochemistry analysis of paraffin-embedded human prostate using E-cadherin (GB11082) at dilution of 1:500 |
| Immunohistochemistry analysis of paraffin-embedded mouse liver using E-cadherin (GB11082) at dilution of 1:500 |
| Immunohistochemistry analysis of paraffin-embedded mouse stomach using E-cadherin (GB11082) at dilution of 1:1000 |
| Immunofluorescence analysis of paraffin-embedded rat colon using E-cadherin (GB11082) at dilution of 1:400 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
