Product Information
Description | Caspase-1 rabbit polyclonal antibody |
Protein full name | cysteinyl aspartate specific proteinase 1 |
Synonyms | CASP1, ICE, IL1BC, P45, caspase 1 |
Immunogen | Recombinant protein corresponding to Mouse Caspase1 |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Cytoplasm |
Predicted MW. | 45 kDa |
Observed MW. | 45 kDa |
Uniprot ID | P29466, P29452, P43527 |
Applications
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1:500-1:1000 | thymus, lung, spleen |
IHC/IF | Human | 1:600-1:1200 | liver cancer, stomach, tonsil |
Background
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Images
| Western blot analysis of Caspase-1 (GB11383) at dilution of 1: 500 |
| Immunohistochemistry of paraffin embedded human breast cancer using caspase1 (GB11383) at dilution of 1: 600 (200x lens) |
| Immunohistochemistry of paraffin embedded human tonsil using caspase1 (GB11383) at dilution of 1: 600 (400x lens) |
| Immunofluorescence of paraffin embedded human stomach using caspase2 (GB11383) at dilution of 1: 600 (400x lens) |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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