Product Information
Description | Wilms Tumor Protein rabbit polyclonal |
Protein full name | Wilms tumor protein homolog |
Synonyms | AEWS-GUD, NPHS4, WAGR, WIT-2, WT33, Wilms tumor, WT1 |
Immunogen | Recombinant protein corresponding to Mouse WT1 |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
IHC | Human, Mouse, Rat | 1: 100-1: 300 | kidney |
IF | Human, Mouse, Rat | 1: 100-1: 300 | kidney |
Background
Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity). Regulates the expression of numerous target genes, including EPO . Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing . Isoform 1 has lower affinity for DNA, and can bind RNA.
Images
| Immunohistochemistry analysis of paraffin-embedded human kidney using WT1 (GB11382) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin-embedded mouse kidney using WT1 (GB11382) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin-embedded rat kidney using WT1 (GB11382) at dilution of 1: 200 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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