Product Information
Description | mTOR rabbit polyclonal |
Protein full name | Serine/threonine-protein kinase mTOR |
Synonyms | FK506-binding protein 12-rapamycin complex-associated protein 1, Mammalian target of rapamycin, Rapamycin target protein 1, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, mTOR |
Immunogen | Recombinant protein corresponding to Mouse mTOR |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 289 kDa |
Observed MW. | 289 kDa |
Uniprot ID |
Applications
applications | species | dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 1000 | testis, liver, brain |
Background
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis.
Images
| Western blot analysis of mTOR (GB11405) at dilution of 1:1000. Lane 1:HeLa cell lysate Lane 2:A431 cell lysate Lane 3:MCF-7 cell lysate Lane 4:Mouse testis tissue lysate Lane 5:Mouse liver tissue lysate Lane 6:Mouse brain tissue lysate Lane 7:Rat testis tissue lysate Lane 8:Rat liver tissue lysate Lane 9:Rat brain tissue lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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