Product Information
Description | Caveolin-1 rabbit polyclonal |
Protein full name | Caveolin-1 |
Synonyms | CAV1, BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21, Caveolin 1 |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Caveolin-1 |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 20 kDa |
Observed MW. | 20 kDa |
Subcellular location | Plasma membrane, Golgi apparatus, Caveola, Peripheral membrane protein |
Uniprot ID |
Applications
applications | species | dilution | Positive tissue |
WB | Mouse, Rat | 1: 800-1: 1000 | heart, lung, skin |
IHC | Mouse, Rat | 1: 1000-1: 3000 | lung, liver |
IF | Mouse, Rat | 1: 1000-1: 3000 | lung, liver |
Background
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex.
Images
| Western blot analysis of Caveolin-1 (GB11409) at dilution of 1:800. Lane 1:U87 cell lysate Lane 2:A549 cell lysate Lane 3:A431 cell lysate Lane 4:Mouse heart tissue lysate Lane 5:Mouse lung tissue lysate Lane 6:Mouse skin tissue lysate Lane 7:Rat heart tissue lysate Lane 8:Rat lung tissue lysate Lane 9:Rat skin tissue lysate |
| Immunohistochemistry analysis of paraffin-embedded mouse lung using Caveolin-1 (GB11409) at dilution of 1:2000 |
| Immunohistochemistry analysis of paraffin-embedded rat liver using Caveolin-1 (GB11409) at dilution of 1:2000 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse testis using Caveolin-1 (GB11409) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse kidney using Caveolin-1 (GB11409) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse stomach using Caveolin-1 (GB11409) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse heart using Caveolin-1 (GB11409) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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