Product Information
Description | c-Jun rabbit polyclonal |
Protein full name | Transcription factor AP-1 |
Synonyms | JUN, AP-1, AP1, c-Jun, Jun proto-oncogene, AP-1 transcription factor subunit, p39, Activator protein 1, Proto oncogene c Jun, JUNC |
Immunogen | KLH conjugated Synthetic peptide corresponding to Human c-Jun. |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Nucleus |
Uniprot ID |
Applications
applications | species | dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 1000-1: 2000 | kidney, lung |
IF | Mouse, Rat | 1: 1000-1: 2000 | ovary, pancreas, bone |
Background
c-Jun in combination with c-Fos, forms the AP-1 early response transcription factor. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. It is known that c-jun plays a role in cellular proliferation and apoptosis of the endometrium throughout the menstrual cycle. The cyclic change of the c-jun protein levels is significant in the proliferation and apoptosis of glandular epithelial cells. The persistent stromal expression of c-jun protein may prevent stromal cells from entering into apoptosis during the late secretory phase
Images
| Immunohistochemistry analysis of paraffin-embedded human kidney using c-Jun (GB11515) at dilution of 1:2000 |
| Immunohistochemistry analysis of paraffin-embedded mouse kidney using c-Jun (GB11515) at dilution of 1:2000 |
| Immunohistochemistry analysis of paraffin-embedded rat lung using c-Jun (GB11515) at dilution of 1:2000 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse ovary using c-Jun (GB11515) at dilution of 1:1000 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse pancreas using c-Jun (GB11515) at dilution of 1:1000 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat bone using c-Jun (GB11515) at dilution of 1:1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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