Артикул
GB11945
быстрая доставка ~4 недели
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Anti -ADAM15 Rabbit pAb
- Описание
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Product Information
Description
ADAM15 rabbit polyclonal antibody
Protein full name
Disintegrin and metalloproteinase domain-containing protein 15
Synonyms
ADAM15, MDC15, ADAM metallopeptidase domain 15
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse ADAM15
Isotype
IgG
Purity
Affinity purification
Predicted MW.
93 kDa
Observed MW.
93 kDa
Uniprot ID
Q13444, O88839, Q9QYV0
Applications
Applications
Species
Dilution
Positive Tissue
WB
Human, Mouse, Rat
1: 500-1: 1000
brain, lung, heart
Background
ADAM15 belongs to a family of transmembrane proteins that contain disintegrin and metalloprotease domains. Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
Images
Western blot analysis of ADAM15 (GB11945) at dilution of 1: 500
Storage
Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.