Артикул
GB11171
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Anti - SIRT1 Rabbit pAb
- Описание
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Product Information
Description
SIRT1 rabbit polyclonal antibody
Protein full name
NAD-dependent protein deacetylase sirtuin-1
Synonyms
SIR2L1,SIR2,hSIR2,SIR2alpha,Sirtuin 1
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse SIRT1
Isotype
IgG
Purity
Affinity purification
Subcellular location
Nucleus, Cytoplasm
Uniprot ID
Q923E4, Q96EB6
Applications
Applications
Species
Dilution
Positive Sample
IHC/IF
Human, Mouse, Rat
1: 500-1: 2000
testis, tonsil
Background
NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD+/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction.
Images
Immunohistochemistry of paraffin embedded human tonsil using SIRT1 (GB11171) at dilution of 1:1000 (400x lens)
Immunohistochemistry of paraffin embedded mouse testis using SIRT1 (GB11171) at dilution of 1:1000 (200x lens)
Immunohistochemistry of paraffin embedded rat testis using SIRT1 (GB11171) at dilution of 1:1000 (200x lens)
Storage
Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.