Артикул
GB111439
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Anti -ACK1 Rabbit pAb
- Описание
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Product Information
Description
ACK1 rabbit polyclonal antibody
Protein full name
Activated CDC42 kinase 1
Synonyms
ACK-1, Non-receptor protein tyrosine kinase Ack, Tyrosine kinase non-receptor protein 2, Tnk2, Ack1
Immunogen
Recombinant protein corresponding to Mouse ACK1
Isotype
IgG
Purity
Affinity purification
Subcellular location
Nucleus, Cell membrane, Cytoplasm
Uniprot ID
O54967
Applications
Applications
Species
Dilution
Positive Sample
IHC/IF
Mouse, Rat
1: 1000-1: 4000
brain
Background
TNK2, also named as ACK1, belongs to the protein kinase superfamily and Tyr protein kinase family. It is a non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. TNK2 transduces extracellular signals to cytosolic and nuclear effectors. It is a downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. TNK2 confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.
Images
Immunohistochemistry of paraffin embedded mouse brain using ACK1 (GB111439) at dilution of 1:2000 (200x lens)
Storage
Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.