Артикул
GB111011
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Anti -ADAMTS1 Rabbit pAb
- Описание
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Product Information
Description
ADAMTS1 rabbit polyclonal antibody
Protein full name
A disintegrin and metalloproteinase with thrombospondin motifs 1
Synonyms
ADAMTS1, ADAMTS, METH1.KIAA1346, A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 1, ADAM metallopeptidase with thrombospondin type 1 motif 1
Immunogen
KLH conjugated Synthetic peptide corresponding to Human ADAMTS1
Isotype
IgG
Purity
Affinity purification
Predicted MW.
106 kDa
Observed MW.
110 kDa
Uniprot ID
P97857, Q9WUQ1
Applications
Applications
Species
Dilution
Positive Tissue
WB
Mouse, Rat
1: 500-1: 1000
heart, brain
Background
ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1), is the founding member of the family of secreted zinc proteases with a multidomain structure. The protein precursor consists of a signal peptide and the following domains: pro, catalytic, disintegrinlike, TS type 1 motif, cysteine rich, spacer and a variable number of thrombospondin type 1 motifs. Based on their substrate specificity, ADAMTS1 and associated family members may be key enzymes in the degradation of cartilage leading to inflammation and arthritis. It is an active protease cleaving alpha 2 macroglobulin, aggrecan and versican. ADAMTS1 is essential for normal growth and the structure and function of the kidneys, adrenal glands and female reproductive organs. It also plays an important role in atherosclerosis.
Images
Western blot analysis of ADAMTS1 (GB111011) at dilution of 1: 500
Storage
Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.