быстрая доставка ~4 недели
Размер
- 10 μg
- 100 μg
- 50 μg
Recombinant Human TNFRSF5/CD40 Protein (RP02226)
- Описание
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Overview
Product name Recombinant Human TNFRSF5/CD40 Protein Catalog No. RP02226 Description Recombinant Human TNFRSF5/CD40 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (CD40(Glu21-Arg193)&mFc(Pro99-Lys330)) of human CD40 (Accession #) fused with a Fc and His Tag at the C-terminal. . Purity > 95% by SDS-PAGE. Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 22 % trehalose is added as protectants before lyophilization. Species Human Background
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.Product information
Synonym CD40; Bp50; CDW40; MGC9013; TNFRSF5; p50 Expression Host HEK293 cells Tag C-mFc&His Swiss-Prot Gene ID Usage guide
Storage Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.Reconstitution Reconstitute with deionized water * For research use only. Not for therapeutic or diagnostic purposes.
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