быстрая доставка ~4 недели
Размер
- 100 μg
- 50 μg
Recombinant Human FLT-3/FLK-2 Protein (RP01138)
- Описание
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Overview
Product name Recombinant Human FLT-3/FLK-2 Protein Catalog No. RP01138 Description Recombinant Human FLT-3/FLK-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Asn541) of human FLT3 (Accession #NP_004110.2) fused with a 6×His tag at the C-terminus. Bio-Activity Measured by its binding ability in a functional ELISA.Immobilized Human FLT3L at 0.5 μg/mL (100 μL/well) can bind FLT3 with a linear range of 0.05-1.3 ng/mL. Purity > 85 % by SDS-PAGE. Endotoxin < 1.0 EU/μg of the protein by LAL method. Formulation Lyophilized from a 0.22 μm filtered solution PBS, pH 7.4.Contact us for customized product form or formulation. Species Human Background
This protein is a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.Product information
Synonym CD135; FLK-2; FLK2; STK1; FLT3 Expression Host HEK293 cells Tag C-His Swiss-Prot Gene ID Usage guide
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. * For research use only. Not for therapeutic or diagnostic purposes.
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