быстрая доставка ~4 недели
Размер
- 100 μg
- 50 μg
Recombinant Mouse TNFRSF1B/TNF-R2/CD120b Protein (RP01131)
- Описание
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Overview
Product name Recombinant Mouse TNFRSF1B/TNF-R2/CD120b Protein Catalog No. RP01131 Description Recombinant Mouse TNFRSF1B/TNF-R2/CD120b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Gly258) of mouse TNFR2 / TNFRSF1B (Accession #NP_035740.2) fused with an Fc tag at the C-terminus. Purity > 95 % by SDS-PAGE. Endotoxin < 1.0 EU/μg of the protein by LAL method. Formulation Lyophilized from a 0.22 μm filtered solution PBS, pH 7.4.Contact us for customized product form or formulation. Species Mouse Background
Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.Product information
Synonym CD120b Protein; Mouse; p75 Protein; Mouse; TNF-alphaR2 Protein; Mouse; TNF-R-II Protein; Mouse; TNF-R2 Protein; Mouse; TNF-R75 Protein; Mouse; TNFalpha-R2 Protein; Mouse; TNFBR Protein; Mouse; Tnfr-1 Protein; Mouse; Tnfr2 Protein; Mouse; TNFR80 Protein; M Expression Host HEK293 cells Tag C-hFc Swiss-Prot Gene ID Usage guide
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. * For research use only. Not for therapeutic or diagnostic purposes.
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