быстрая доставка ~4 недели
Размер
- 10 μg
- 100 μg
- 1000 μg
- 20 μg
- 200 μg
- 5 μg
- 50 μg
- 500 μg
Active Recombinant Human Fc-gamma RIIa/CD32a(H167R) Protein (RP01383)
- Описание
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Overview
Product name Active Recombinant Human Fc-gamma RIIa/CD32a(H167R) Protein Catalog No. RP01383 Description Active Recombinant Human Fc-gamma RIIa/CD32a(H167R) Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala36-Ile218(R167)) of human FCGR2A/CD32a(R167) (Accession #NP_001129691.1) fused with a Fc, 6×His tag at the C-terminus. Bio-Activity Measured by its binding ability in a functional ELISA. Immobilized Human FCGR2A/CD32a(R167) at 1 μg/mL (100 μL/well) can bind FCGR2A Rabbit pAb with a linear range of 0.977-175.35 ng/mL. Purity > 95% by SDS-PAGE. Endotoxin <0.1EU/ug Formulation Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Species Human Background
Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. The activating isoform, CD32A, is expressed on monocytes, neutrophils, platelets and dendritic cells. CD32A is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells), where inhibitory ITIM-bearing receptors may also be coexpressed and co-engaged by specific ligands. CD32A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. The responses can be modulated by signals from the coexpressed inhibitory receptors such as CD32B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.Product information
Synonym CD32a; FCGR2A; CD32; FCG2 ; FCGR2A1; IGFR2 Expression Host HEK293 cells Tag C-hFc&His Swiss-Prot Gene ID Usage guide
Storage Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. * For research use only. Not for therapeutic or diagnostic purposes.
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