быстрая доставка ~4 недели
Размер
- 10 μg
- 1000 μg
- 50 μg
- 500 μg
Recombinant Mouse IL-4RA/CD124 Protein (RP00568)
- Описание
-
Overview
Product name Recombinant Mouse IL-4RA/CD124 Protein Catalog No. RP00568 Description Recombinant Mouse IL-4RA/IL-4 R alpha Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Ile26-Arg233) of mouse IL-4RA/IL-4 R alpha (Accession #P16382) fused with an Fc tag at the C-terminus. Purity > 90% by SDS-PAGE. Endotoxin < 1 EU/μg of the protein by LAL method. Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation. Species Mouse Background
Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to thetype I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions asreceptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgEproduction and chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RAcan signal through activation of insulin receptor substrates, IRS1/IRS2. The functional IL4 receptor is formed byinitial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immunecells, IL-4RA creates a type I receptor. In non-immune cells, it forms a type II receptor with of IL13RA1. IL4R canalso interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP.Product information
Synonym Interleukin-4 receptor subunit alpha; IL-4R-alpha; CD124; IL4-BP; Soluble IL-4R-alpha Expression Host HEK293 cells Tag C-Fc Swiss-Prot Gene ID Usage guide
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. * For research use only. Not for therapeutic or diagnostic purposes.
Product Protocols