быстрая доставка ~4 недели
Размер
- 10 μg
- 100 μg
- 50 μg
- 500 μg
Recombinant Human IL-21 Protein (RP01312)
- Описание
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Overview
Product name Recombinant Human IL-21 Protein Catalog No. RP01312 Description Recombinant Human IL-21 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln25-Ser155) of human IL-21 (Accession #NP_068575.1) fused with an 6×His tag at the C-terminus. Bio-Activity Measured by its binding ability in a functional ELISA. Immobilized Human IL21R at 2 μg/mL (100 μL/well) can bind Human IL21 with a linear range of 0.078-0.973 μg/mL. Purity > 95% by SDS-PAGE. Endotoxin < 1.0 EU/μg of the protein by LAL method. Formulation Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Species Human Background
IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).Product information
Synonym CVID11 ; IL-21 Protein; Za11 Protei Expression Host HEK293 cells Tag C-His Swiss-Prot Gene ID Usage guide
Storage Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. * For research use only. Not for therapeutic or diagnostic purposes.
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