быстрая доставка ~4 недели
Размер
- 100 μg
- 20 μg
- 50 μg
Recombinant Human IL-37/IL-1F7 Protein (RP02509)
- Описание
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Overview
Product name Recombinant Human IL-37/IL-1F7 Protein Catalog No. RP02509 Description Recombinant Human IL-37 Protein is produced by Escherichia coli expression system. The target protein is expressed with sequence of Human IL-37 fused with polyhistidine tag at the C-terminus Bio-Activity Measured by its ability to inhibit IL-8 secretion in human PBMCs. The ED50 for this effect is <0.9 μg/mL. Purity > 95% by SDS-PAGE. Endotoxin <0.1EU/ug Formulation Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Species Human Background
Decreasing synthesis of IL-37 in PBMCs will cause increasing production of pro-inflammatory cytokines such as IL-1 alpha, IL-1 beta, IL-6 and TNF- alpha. The IL-37 work as an innate inflammatory inhibitor is also proved by its high expression in synovial tissue from rheumatoid arthritis patients. Full length IL-37 locates mainly in the cytoplasm, and it can translocate to the nucleus after activation through cleavage by CASP1, then exerts its activity by directly interacting with SMAD3.Product information
Synonym IL37; FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H; IL-1H4; IL-1RP1; IL-37; IL1F7; IL1H4; IL1RP1 Expression Host E. coli Tag C-His Swiss-Prot Gene ID Usage guide
Storage Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. * For research use only. Not for therapeutic or diagnostic purposes.
Product Protocols