быстрая доставка ~4 недели
Размер
- 100 μg
- 20 μg
- 50 μg
Recombinant Mouse IL-18 Protein (RP02521)
- Описание
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Overview
Product name Recombinant Mouse IL-18 Protein Catalog No. RP02521 Description Recombinant Mouse IL-18 Protein is produced by Escherichia coli expression system. The target protein is expressed with sequence of Mouse IL-18 fused with polyhistidine tag at the C-terminus Bio-Activity Measured by its ability to inhibit IFN gamma secretion in KG-1 cells. The ED50 for this effect is < 0.5 μg/mL. Purity > 98% by SDS-PAGE. Endotoxin <0.1EU/ug Formulation Lyophilized from a 0.22 μm filtered solution of PBS, pH 8.0. Species Mouse Calculated MW 22kDa Background
Interleukin-18 (L-18) is a cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.Product information
Synonym Interleukin-18; Il18; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1gamma; IL-1 gamma; Igif; Igif; Il-18 Expression Host E. coli Tag C-His Swiss-Prot Gene ID Usage guide
Storage Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. * For research use only. Not for therapeutic or diagnostic purposes.
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