быстрая доставка ~4 недели
Размер
- 100 μg
- 20 μg
- 50 μg
Recombinant Human BMP-7 Protein (RP02513)
- Описание
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Overview
Product name Recombinant Human BMP-7 Protein Catalog No. RP02513 Description Recombinant Human BMP-7 Protein is produced by Escherichia coli expression system. The target protein is expressed with sequence of Human BMP-7 fused with polyhistidine tag at the C-terminus Bio-Activity Measured by its ability to inhibit alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is <0.65 μg/mL. Purity > 98% by SDS-PAGE. Endotoxin <0.1EU/ug Formulation Lyophilized from a 0.22 μm filtered solution of 20 mM sodium citrate, 0.2 M NaCl, pH 3.5. Species Human Background
BMP-7 (Bone morphogenetic protein 7) is a bone morphogenetic protein which belongs to the TGF-β superfamily. OP-1 is expressed in the brain, kidneys, and bladder. BMP-7 may be involved in bone homeostasis and plays a key role in the transformation of mesenchymal cells into bone and cartilage. The phosphorylation of SMAD1 and SMAD5 can be induced by BMP-7, which in turn induce transcription of numerous osteogenic genes. BMP-7 treatment can also induce all of the genetic markers of osteoblast differentiation in many cell types. Human recombinant BMP-7 protein can be used to aid in the fusion of vertebral bodies to prevent neurologic trauma. It also functions in the treatment of tibial non-union, frequently in cases where a bone graft has failed. It is found that BMP7 has the potential for treatment of chronic kidney disease.Product information
Synonym BMP7; OP-1 Expression Host E. coli Tag C-His Swiss-Prot Gene ID Usage guide
Storage Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. * For research use only. Not for therapeutic or diagnostic purposes.
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