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Размер
- 100 T
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ABflo® 594 Rabbit anti-Human IL-17RB mAb (A24317)
- Описание
- Характеристики
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Overview
Product name ABflo® 594 Rabbit anti-Human IL-17RB mAb Catalog No. A24317 Host species Rabbit Purification method Affinity purification Isotype IgG CloneNo. ARC62205-ABflo594 Background
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.Immunogen information
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 18-289 of human IL-17RB (NP_061195.2). Sequence REPTVQCGSETGPSPEWMLQHDLIPGDLRDLRVEPVTTSVATGDYSILMNVSWVLRADASIRLLKATKICVTGKSNFQSYSCVRCNYTEAFQTQTRPSGGKWTFSYIGFPVELNTVYFIGAHNIPNANMNEDGPSMSVNFTSPGCLDHIMKYKKKCVKAGSLWDPNITACKKNEETVEVNFTTTPLGNRYMALIQHSTIIGFSQVFEPHQKKQTRASVVIPVTGDSEGATVQLTPYFPTCGSDCIRHKGTVVLCPQTGVPFPLDNNKSKPGG Gene ID Swiss Prot Synonyms IL17RB; CRL4; EVI27; IL17BR; IL17RH1; interleukin-17 receptor B Calculated MW 31kDa/55kDa Observed MW Applications
Reactivity Human Tested applications FC Recommended dilution - FC 5 μl per 10^6 cells in 100 μl volume
Storage buffer Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.03% proclin300, 0.2% BSA, 50% glycerol, pH7.3.Key application Flow Cytometry Positive samples Cellular location Cell membrane, Secreted, Single-pass type I membrane protein 
Flow cytometry:1X10^6 MOLT-4 cells (negative control, Left) and HepG2 cells (Right) were surface-stained with ABflo® 594 Rabbit anti-Human IL-17RB mAb(A24317, 5 μl/Test, orange line) or ABflo® 594 Rabbit IgG isotype control (A23821, 5 μl/Test, blue line). Non-fluorescently stained cells were used as blank control (red line).
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Key applications Flow Cytometry Host species Кролик Antibody type Primary Antibodies Reactivity Человек Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 18-289 of human IL-17RB (NP_061195.2). Isotype IgG