Артикул
GB111004
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Anti -L1CAM Rabbit pAb
- Описание
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Product Information
Description
L1CAM rabbit polyclonal
Protein full name
Neural cell adhesion molecule L1
Synonyms
NCAM-L1, CD171,L1cam, Caml1, CD171 antigen, HSAS, MASA
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse L1CAM
Isotype
IgG
Purity
Affinity purification
Subcellular location
Predicted MW.
141 kDa
Observed MW.
141/220 kDa
Uniprot ID
Applications
Applications
Species
Dilution
Positive Tissue
WB
Mouse, Rat
1: 500-1: 1000
brain, cerebral cortex, hippocampus, spinal cord
IHC
Mouse, Rat
1: 1000-1: 4000
thalamus, brain, cerebellum
IF
Mouse, Rat
1: 500-1: 1000
thalamus, brain, cerebellum
Background
The protein encoded by L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of L1CAM results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.
Images
Western blot analysis of L1CAM (GB111004) at dilution of 1: 1000
Lane 1: Mouse brain tissue lysate
Lane 2: Mouse cerebral cortex tissue lysate
Lane 3: Mouse hippocampus tissue lysate
Lane 4: Mouse spinal cord tissue lysate
Lane 5: Rat brain tissue lysate
Lane 6: Rat cerebral cortex tissue lysate
Lane 7: Rat hippocampus tissue lysate
Immunohistochemistry analysis of paraffin-embedded mouse thalamus using L1CAM (GB111004) at dilution of 1: 2000
Immunohistochemistry analysis of paraffin-embedded rat cerebellum using L1CAM (GB111004) at dilution of 1: 2000
Storage
Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.